We have received notice of award from the National Institute of Allergy and Infectious Diseases for our project titled “Identification of Anti-Staphylococcus aureus Metabolites Produced by Dolosigranulum pigrum from the Human Nose”!
The long-term goal of this work is to understand the chemical mechanisms used by Dolosigranulum pigrum, a beneficial bacterial species found in the human nose, to compete against co-occurring Staphylococcus aureus, and to develop therapeutics against this pathobiont. The overall objectives in this application are to (i) isolate and identify ribosomally synthesized and post-translationally modified peptides (RiPPs) that are produced by D. pigrum to inhibit S. aureus and (ii) establish a genetic system for D. pigrum that will enable future research into this beneficial organism.
For more information, please visit NIH RePORTER.